Vinculin Recombinant Rabbit mAb (S-1635-6)

產(chǎn)品型號：S0B1132

更新時間：2025-10-07

廠商性質(zhì)：生產(chǎn)廠家

訪問量：125

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ELISA試劑盒抗體試劑盒二抗試劑盒二抗其它流式抗體瓊脂糖/磁珠偶聯(lián)抗體抗Payload抗體泛修飾抗體標(biāo)簽/內(nèi)參抗體功能性抗體 Biosimilar抗體偶聯(lián)抗體配對抗體病理/IHC抗體

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產(chǎn)品介紹

Vinculin is a critical cytoskeletal protein that plays a significant role in cell adhesion, migration, and mechanical force transmission. It is highly enriched in regions where cells contact one another and the underlying substratum. Vinculin is involved in the formation and stabilization of focal adhesions, which are essential for cell-matrix interactions. It binds to several proteins, including talin, α-actinin, and paxillin, to link the actin cytoskeleton to integrins, facilitating cell adhesion and migration. Vinculin helps in transmitting mechanical forces from the extracellular matrix to the actin cytoskeleton, playing a crucial role in mechanotransduction. It can undergo conformational changes upon binding to different partners, which is essential for its function in force transmission. Vinculin stimulates actin polymerization and recruits actin remodeling proteins, which is vital for cell protrusion and migration.

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