Mouse Anti-Human CD184 Antibody (S-R635)

產(chǎn)品型號(hào)：S0B5037

更新時(shí)間：2025-10-08

廠商性質(zhì)：生產(chǎn)廠家

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ELISA試劑盒抗體試劑盒二抗試劑盒二抗其它流式抗體瓊脂糖/磁珠偶聯(lián)抗體抗Payload抗體泛修飾抗體標(biāo)簽/內(nèi)參抗體功能性抗體 Biosimilar抗體偶聯(lián)抗體配對(duì)抗體病理/IHC抗體

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產(chǎn)品介紹

CD184, also known as CXCR4, is a G protein-coupled receptor with seven transmembrane domains that serves as the receptor for stromal cell-derived factor-1 （SDF-1, also known as CXCL12）. It is widely expressed in various tissues, including peripheral blood leukocytes, spleen, thymus, bone marrow, heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, cerebellum, and endothelial cells. CXCR4 plays crucial roles in multiple physiological processes, such as cell migration, hematopoiesis, vascularization, neural development, and wound healing. It also acts as a co-receptor for T-cell tropic strains of HIV-1, facilitating viral entry into CD4+ cells. In cancer, CXCR4 is overexpressed in many tumor types and is associated with increased invasiveness, metastasis, and poor prognosis. Additionally, CXCR4 is involved in the homing of hematopoietic stem cells to the bone marrow and the retention of aged neutrophils.

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