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產(chǎn)品中心抗體/抗原流式抗體S0B5123Mouse Anti-Rat CD31 Antibody (S-R587)
產(chǎn)品型號：S0B5123
更新時間：2025-10-08
廠商性質(zhì)：生產(chǎn)廠家
訪問量：78
服務熱線15855403091
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CD31, also known as Platelet Endothelial Cell Adhesion Molecule-1 （PECAM-1）, is a transmembrane glycoprotein belonging to the immunoglobulin superfamily, primarily expressed by endothelial cells, platelets, and certain leukocytes. Its structure includes six extracellular immunoglobulin-like domains, which mediate cell-cell adhesion through homophilic （CD31-CD31） or heterophilic interactions. CD31 plays a critical role in maintaining vascular integrity, regulating vascular permeability, and modulating inflammatory responses, particularly by facilitating the transendothelial migration of leukocytes to sites of inflammation. Additionally, it is involved in angiogenesis, inhibition of apoptosis, and intracellular signaling pathways （e.g., Src kinase pathways）. Clinically, CD31 is commonly used as a vascular endothelial marker in pathological diagnosis and is associated with pathological processes such as atherosclerosis and tumor metastasis.
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