AMACR/p504s Recombinant Rabbit mAb (Alexa Fluor??555 Conjugate) (SDT-401-29)

產(chǎn)品型號：S0B1573

更新時(shí)間：2025-10-10

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產(chǎn)品介紹

α-Methylacyl-CoA racemase （AMACR; P504S） catalyzes a key chiral inversion step in the metabolism of branched-chain fatty acids, ibuprofen and related drugs. Protein levels are increased in all prostate and some other cancer cells and it is used as a marker （P504S）. The enzyme requires no cofactors and catalyzes its reaction by a stepwise 1,1-proton transfer via an enolate intermediate. The biological role of AMACR in cancer is complex, linking lipid metabolism with nuclear receptor （e.g. FXR and PPAR） activity and expression of enzymes such as cyclooxygenase-2 （COX-2）. A number of rationally designed AMACR inhibitors have been reported in the literature as potential cancer treatments. The opportunities and challenges for development of acyl-CoA esters as inhibitors are discussed from a medicinal chemical viewpoint. Other challenges for drug development include the problems in assaying enzymatic activity and the prediction of structure-activity relationships （SAR）. [PMID: 23376124]

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